New insights into the catalytic mechanism of the SARS-CoV-2 main protease: an ONIOM QM/MM approach

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Investigating the Mechanism of Action of SARS-CoV-2 Virus for Drug Designing: A Review

Coronavirus Disease 2019 (COVID-19) is a viral pneumonia emerged in December 2019 in Wuhan, China. Its cause is a new virus from the coronavirus family scientifically named Coronavirus Acute Respiratory Syndrome 2 (SARS-CoV-2). In this review study, articles published in English until March 23, 2020 on new coronavirus infection were reviewed. These articles are obtained by searching in PubMed, ...

متن کامل

the use of appropriate madm model for ranking the vendors of mci equipments using fuzzy approach

abstract nowadays, the science of decision making has been paid to more attention due to the complexity of the problems of suppliers selection. as known, one of the efficient tools in economic and human resources development is the extension of communication networks in developing countries. so, the proper selection of suppliers of tc equipments is of concern very much. in this study, a ...

15 صفحه اول

SARS-COV-2 Virus; Immune Responses and The Immunopathogenesis

Abstract Background and Objectives Clinical features of SARS-COV-2 virus include fever, headache, cough, sore throat, and shortness of breath, and in severe forms it leads to disseminated intravascular coagulation, septic shock, and ultimately death. Excessive secretion of proinflammatory cytokines such as TNF-α, IL-6, and IL-1 leads to cytokine storms in this disease. The emergence of new va...

متن کامل

Introducing the SARS-CoV-2 and discussing the possible origin of the virus

The emergence of the dangerous and deadly COVID-19 disease in late 2019 in Wuhan, China, and its rapid spread has had a profound global impact on health, mental security, the economy, culture and politics of various countries, drawing the attention of the medical community and related sciences for identification and treatment of this disease. Various studies on the disease have identified a new...

متن کامل

Achieving Effective Treatment Goals against New Coronavirus (SARS-CoV-2) by Identifying the Molecular Details of the Virus Genome

Introduction: We are currently faced with a global epidemic of a new coronavirus (SARS-CoV-2) that It affects not only thousands of people in China, but all over the world. The rapid increase in cases appears to be related to the active genome of the virus, which may affect its pathogenesis. An understanding of the novel coronavirus genomic organization will help us in understanding their origi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Molecular Diversity

سال: 2021

ISSN: 1381-1991,1573-501X

DOI: 10.1007/s11030-021-10259-7